Publications & References

Driven by the Power of Mitochondria


  1. Mitochondrial augmentation of hematopoietic stem cells in children with single large-scale mitochondrial DNA deletion syndromes.
    Jacoby E, Bar-Yosef O, Gruber N, Lahav.E, Varda-Bloom N, Bolkier Y, Bar D, Ben Yakir-Blumkin M, Barak S, Eisenstein E, Ahonniska-Assa J, Silberg T, Krasovsky T, Bar O, Erez N, Bielorai B, Golan H, Dekel B, Besser MJ, Pozner G, Khoury H, Jacobs A, Campbell J, Herskovitz E, Sher N, Anikster Y, Yivgi-Ohana N, Toren A.
    Sci. Transl. Med. 14, eabo3724 (2022)
  2. Mitochondrial augmentation of CD34+ cells from healthy donors and patients with mitochondrial DNA disorders confers functional benefit.
    Jacoby E, Ben Yakir-Blumkin M, Blumenfeld-Kan S, Brody Y, Meir A, Melamed-Book N, Napso T, Pozner G, Saadi E, Shabtay-Orbach A, Yivgi-Ohana N, Sher N, Toren A.
    NPJ Regen Med. 2021 Sep 24;6(1):58. doi: 10.1038/s41536-021-00167-7
  3. Clark MA, Shay JW. Mitochondrial transformation of mammalian cells. Nature 1982;295:605-7.
  4. Ahmad T, Mukherjee S, Pattnaik B, et al. Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy. EMBO J 2014;33:994-1010.
  5. King MP, Attardi G. Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA. Cell 1988;52:811-9.
  6. Spees JL, Olson SD, Whitney MJ, Prockop DJ. Mitochondrial transfer between cells can rescue aerobic respiration. Proc Natl Acad Sci U S A 2006;103:1283-8.
  7. Islam MN, Das SR, Emin MT, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med 2012;18:759-65.
  8. Hofling AA, Vogler C, Creer MH, Sands MS. Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease. Blood 2003;101:2054-63.
  9. Rocca CJ, Goodman SM, Dulin JN, et al. Transplantation of wild-type mouse hematopoietic stem and progenitor cells ameliorates deficits in a mouse model of Friedreich’s ataxia. Sci Transl Med 2017;9.
  10. Rotig A, Cormier V, Blanche S, et al. Pearson’s marrow-pancreas syndrome. A multisystem mitochondrial disorder in infancy. J Clin Invest 1990;86:1601-8.
  11. Elliott, H. R., Samuels, D. C., Eden, J. A., Relton, C. L. & Chinnery, P. F. Pathogenic mitochondrial DNA mutations are common in the general population. American journal of human genetics 83, 254-260, doi:10.1016/j.ajhg.2008.07.004 (2008).
  12. Piero Farruggia, Floriana Di Marco, and Carlo Dufour. Pearson syndrome. EXPERT REVIEW OF HEMATOLOGY, 2018. VOL. 11, NO. 3, 239–2
  13. Gr_ainne S. Gorman et al., Prevalence of Nuclear and Mitochondrial DNA Mutations Related to Adult Mitochondrial Disease. ANN NEUROL 2015;77:753–759
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