Publications & References

Driven by the Power of Mitochondria


Publications on MAT

  1. Mitochondrial augmentation of hematopoietic stem cells in children with single large-scale mitochondrial DNA deletion syndromes.
    Jacoby E, Bar-Yosef O, Gruber N, Lahav.E, Varda-Bloom N, Bolkier Y, Bar D, Ben Yakir-Blumkin M, Barak S, Eisenstein E, Ahonniska-Assa J, Silberg T, Krasovsky T, Bar O, Erez N, Bielorai B, Golan H, Dekel B, Besser MJ, Pozner G, Khoury H, Jacobs A, Campbell J, Herskovitz E, Sher N, Anikster Y, Yivgi-Ohana N, Toren A.
    Sci. Transl. Med. 14, eabo3724 (2022)
  2. Mitochondrial augmentation of CD34+ cells from healthy donors and patients with mitochondrial DNA disorders confers functional benefit.
    Jacoby E, Ben Yakir-Blumkin M, Blumenfeld-Kan S, Brody Y, Meir A, Melamed-Book N, Napso T, Pozner G, Saadi E, Shabtay-Orbach A, Yivgi-Ohana N, Sher N, Toren A.
    NPJ Regen Med. 2021 Sep 24;6(1):58. doi: 10.1038/s41536-021-00167-7

Major publications in the space

  1. Clark MA, Shay JW. Mitochondrial transformation of mammalian cells. Nature 1982;295:605-7. First demonstration that isolated mitochondria can enter cells in vitro.
  2. Spees JL, Olson SD, Whitney MJ, Prockop DJ. Mitochondrial transfer between cells can rescue aerobic respiration. Proc Natl Acad Sci U S A 2006. First in vitro demonstration of rescue due to mitochondrial transfer.
  3. Islam MN, Das SR, Emin MT, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med 2012. First in vivo demonstration of rescue due to mitochondrial transfer.
  4. Hofling AA, Vogler C, Creer MH, Sands MS. Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease. Blood 2003. Demonstration of in vivo effects of HSPCs.
  5. Rocca CJ, Goodman SM, Dulin JN, et al. Transplantation of wild-type mouse hematopoietic stem and progenitor cells ameliorates deficits in a mouse model of Friedreich’s ataxia. Sci Transl Med 2017. Demonstration of in vivo effects of HSPCs.
  6. Rotig A, Cormier V, Blanche S, et al. Pearson’s marrow-pancreas syndrome. A multisystem mitochondrial disorder in infancy. J Clin Invest 1990. Review on Pearson Syndrome.
  7. Elliott, HR, Samuels, DC, Eden, JA, Relton, CL & Chinnery, PF. Pathogenic mitochondrial DNA mutations are common in the general population. American Journal of Human Genetics 2008.
  8. Farruggia, P, Di Marco, F and Dufour, C. Pearson syndrome. Expert Review Hematol, 2018. Review on Pearson Syndrome.
  9. Borcherding N, Brestoff J. The power and potential of mitochondrial transfer. Nature 2023. Review on mitochondrial transfer.
  10. Liu et al, A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies. J Clin Invest 2024.